On Mon, Nov 9, 2020 at 7:53 PM Lawrence Crowell <
[email protected]> wrote:

*>My understanding is this uses mRNA that codes for spike proteins. The m
> stands for messenger, where this is read by ribosomes in translation of
> genetic information into polypeptides. It appears this makes its way into
> our ribosomes and starts generating these virion proteins that our immune
> system will then respond to.*


The one problem with vaccines like that is that naked mRNA Is pretty
fragile so it must be kept at dry ice temperatures until just before it is
actually injected, and that greatly complicates any plan for large scale
distribution. The fact that it requires two shots 21 days apart makes it
even more complicated.  The Johnson and Johnson vaccine is more
conventional, it uses a harmless virus as a vector to get the genetic
material into cells and so it doesn't need such extreme refrigeration, but
nobody knows yet if it's as effective as the Pfizer vaccine.

John K Clark

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