On Tuesday, November 10, 2020 at 6:57:42 AM UTC-6 [email protected] wrote:

> On Mon, Nov 9, 2020 at 7:53 PM Lawrence Crowell <[email protected]> 
> wrote:
>
> *>My understanding is this uses mRNA that codes for spike proteins. The m 
>> stands for messenger, where this is read by ribosomes in translation of 
>> genetic information into polypeptides. It appears this makes its way into 
>> our ribosomes and starts generating these virion proteins that our immune 
>> system will then respond to.*
>
>
> The one problem with vaccines like that is that naked mRNA Is pretty 
> fragile so it must be kept at dry ice temperatures until just before it is 
> actually injected, and that greatly complicates any plan for large scale 
> distribution. The fact that it requires two shots 21 days apart makes it 
> even more complicated.  The Johnson and Johnson vaccine is more 
> conventional, it uses a harmless virus as a vector to get the genetic 
> material into cells and so it doesn't need such extreme refrigeration, but 
> nobody knows yet if it's as effective as the Pfizer vaccine.
>
> John K Clark
>

I read about just that point. This requires low temperature facilities, 
where there are places they are not available.

LC

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