So then we know which nucleic acid sequence will cause cells to produce
the desired protein, and we can use CRISPR to modify DNA to produce the
RNA that will produce the desired protein...if we knew what protein was
desired.
Can superpowers be far behind?
Brent
On 9/16/2022 10:03 AM, John Clark wrote:
AlphaFold solved the protein folding problem some time ago and now,
judging from two articles in today's issue of the journal Science, it
looks like the inverse problem has also been solved, the protein
design problem. If you tell a program called "ProteinMPNN" that you
want a 3-D protein that has an activation site that will perform a
very specific function, and has the proper scaffolding to keep that
activation site stable, and is also shaped in just the right way so
that it can fit into a very tight corner where it is needed like a key
into a lock, then ProteinMPNN will tell you what linear sequence of
amino acids will fold up into that 3-D shape. I think this is a very
big deal, the implications for medicine are obvious but it also
signifies a huge advance in Nanotechnology because the authors claim
the 3-D shape the sequence of amino acids folds up into is within 0.06
Nanometers of the requested shape, and Nanotechnology is about placing
atoms exactly where you want them to go, and enzymes are proteins and
they act like little machines.
Robust deep learning–based protein sequence design using ProteinMPNN
<https://www.science.org/doi/10.1126/science.add2187>
Hallucinating symmetric protein assemblies
<https://www.science.org/doi/10.1126/science.add1964>
John K Clark
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