Impressive result indeed. I can see this as a logical extension of
work done in the '90s where crayfish brains were plasticised, sliced
then imaged under electron microscopes, giving a 3D dataset of the
brain structure. Nowhere near as detailed as this, though.

Next step is to calculate the complexity of the drosophila brain. I did
that a few years back for the C. Elegans brain - although I doubt my
algorithms will be up to snuff, as they tend to be combinatorially
complex - but who knows, I might get lucky.

Cheers

On Thu, Oct 03, 2024 at 02:44:45PM -0400, John Clark wrote:
> A fly has been uploaded. That's the takeaway I got after reading an article in
> yesterday's issue of the journal Nature. Apparently Sebastian Seung, a leader
> of the project, had a similar thought because he is quoted as saying:
> 
> “Mind uploading has been  science fiction, but now mind uploading — for a fly,
> at least — is becoming mainstream science.”
> 
> They put the brain of an adult fly in a bath of liquid plastic which soon
> hardened into a solid block. Then they sliced the entire brain into 7,050 
> super
> thin slices and took 21 million high resolution pictures of it. Then they 
> wrote
> a computer program that could look at all those pictures and trace which 
> neuron
> was connected to which; from that they were able to conclude that the fly 
> brain
> had 139,255 neurons and 50 million connections. Pretty impressive considering
> that previously the best neuronal map was that of a worm that only had 385
> neurons, but that's not even the best part. They used the information about 
> how
> those 139,255 neurons were wired up to make a simulated fly brain on a
> computer, and they obtained typical fly behavior! Sebastian Seung said:
> 
> "We show that activation of sugar-sensing or water-sensing gustatory neurons 
> in
> the computational model accurately predicts neurons that respond to tastes and
> are required for feeding initiation. In addition, using the model to activate
> neurons in the feeding region of the Drosophila brain predicts those that
> elicit motor neuron firing. Our results demonstrate that modelling brain
> circuits using only synapse-level connectivity and predicted neurotransmitter
> identity generates experimentally testable hypotheses and can describe 
> complete
> sensorimotor transformations."
> 
> The researchers say their next target is uploading a mouse brain which has
> about 1000 times more neurons than a fly brain.
> 
> A Drosophila computational brain model reveals sensorimotor processing
> 
>  John K Clark    See what's on my new list at  Extropolis
> vo3
> 
> 
> 
> 
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