Miles,

There is an issue with MS05-019 which, to make a long story short, will cause 
the symptoms that you are seeing, i.e. SMTP traffic to other sites halts after 
several hours or days.  Its all dependent on the volume of traffic and 
configuration of the intermediate network hardware. Its an OS issue so it can 
potentially affect apps other than Exchange.
Please see kb898060 for details and the fix/workaround.
Good luck and please let us know how you make out.

Sam


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