I hope some real experts can pin it down for you, but here's what lil'ole me would thrash around with:

turn to Tracking and see exactly what happened to those failed replies

send a message to postmaster<at>failedreplyaddress to see if gets through

use the dnsstuff.com test email on the failed reply addresses

see whether the original message was to a mailing list. Sending or replying to a mailing list often results in some bounces

make sure the users aren't tampering with the reply address

spam and content filters sometimes lget confused and lie about why they're bouncing a message. That would account for why sometimes it works and sometimes not. All you can do in that case is hope that eventually the admins over there will catch on.

----- Original Message ----- From: "Tony Nguyen" <[EMAIL PROTECTED]>
To: "Exchange Discussions" <[email protected]>
Sent: Tuesday, October 10, 2006 9:43 PM
Subject: Unknown User


I need some help with this please. I have been report from some of my users
say that when they do a reply to an email it get returned with SMTP; 550
5.1.1 User unknown and some time the reply work fine. Where should I start
trouble shooting this. I never had this problem before until a couple of
days ago. Nothing was change in the system too.

Thank
Tony


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