As the rest have stated... first rule out a virus.  If a virus is not the 
cause
This article has a section about relay restrictions, it might help you 
decide what restrictions you need:
http://support.microsoft.com/support/kb/articles/q230/2/35.asp


>From: "Murphy, Brian" <[EMAIL PROTECTED]>
>Reply-To: "Exchange Discussions" <[EMAIL PROTECTED]>
>To: "Exchange Discussions" <[EMAIL PROTECTED]>
>Subject: RE: IIS SMTP relay for Exchange - Is my relay being used by other  
>    s?
>Date: Tue, 20 Nov 2001 14:49:25 -0600
>
>Rule out the virus first.  Download some type of AV and scan.
>
>-----Original Message-----
>From: Jesse Rink [mailto:[EMAIL PROTECTED]]
>Sent: Tuesday, November 20, 2001 2:39 PM
>To: Exchange Discussions
>Subject: Re: IIS SMTP relay for Exchange - Is my relay being used by
>others?
>
>
>Version 4.0 so the Q article doesn't apply..  Thanks anyway.  Is there a
>comparable Q article for IIS4?
>
>Also, I should mention that on my IIS relay box, under the Remote Domain
>properties, the box labeled "Allow incoming mail to be relayed to this
>domain" *IS* checked.  Not sure why.  Would this be the cause?  Or would
>it still be a virus as some are saying?
>
>Thanks
>
>
> > What version of IIS? the following article is for IIS 5
> > http://support.microsoft.com/support/kb/articles/q310/3/56.asp
> >
> >
> > >From: "Jesse Rink" <[EMAIL PROTECTED]>
> > >Reply-To: "Exchange Discussions" <[EMAIL PROTECTED]>
> > >To: "Exchange Discussions" <[EMAIL PROTECTED]>
> > >Subject: IIS SMTP relay for Exchange -  Is my relay being used by 
>others?
> > >Date: Tue, 20 Nov 2001 14:23:00 -0600
> > >
> > >Okay.  Here's the low-down.
> > >
> > >I have an Exchange 5.5 server on the inside interface of our firewall 
>and
> > >and IIS SMTP relay server on the DMZ interface of our firewall.  This 
>has
> > >been running for several months without any problems.
> > >
> > >Yesterday I reviewed the daily network bandwidth chart for our T1 line
>out
> > >the to internet and found the inbound traffic was WAY higher (my eyes
> > >almost popped out of my sockets) than usual.  This was highly 
>noticeable
> > >in that the inbound traffic continued into the late hours of the night.
> > >Normally, after 5pm, network inbound/outbound traffic is dead.
> > >
> > >I tried figuring out what all of a sudden is causing this increased
> > >traffic and am beginning to suspect the IIS SMTP relay box.  
>Performance
> > >analysis on the box shows that the CPU utilization is much higher than
> > >usual (mainly from inetinfo.exe).  After further investigating, I 
>noticed
> > >that the c:\inetpub\mailroot\queue directory is suddenly full (1500
> > >messages) of .rtr and .eml files (can someone explain the difference
> > >between these?).
> > >
> > >Not only are there 1500+ .rtr and .eml files in the queue, but the
> > >messages themselves are not originating from or destined to 
>whitnall.com
> > >(my domain).
> > >
> > >I'm assuming someone (most of the messages are from hotmail.com 
>accounts
> > >and contain PORN links) is using our smtp relay...
> > >
> > >Can someone please help me address this problem?  Not sure how to
>proceed.
> > >  Thanks
> > >
> > >reply here or via email
> > >[EMAIL PROTECTED]
>
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