On .NET Framework 4.6.1 and Exchange compatibility - Exchange Team Blog
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http://blogs.technet.com/b/exchange/archive/2016/02/10/on-net-framework-4-6-1-and-exchange-compatibility.aspx
We wanted to post a quick note to call out that since yesterday, the
.NET Framework 4.6.1 has been made a recommended update on WU (Windows
Update).
As we have already stated in the Exchange Supportability Matrix
<https://technet.microsoft.com/en-us/library/ff728623%28v=exchg.150%29.aspx>,
at this time, this version of .NET framework is /not/ supported by
Exchange. In fact, we know of some issues
<http://support.microsoft.com/en-us/kb/3095369> if it is installed.
We are working with the .NET team to ensure that Exchange customers have
a smooth transition to .NET Framework 4.6.1, but in the meantime, delay
this particular .NET update on your Exchange servers (information on how
this can be accomplished can be found in the KB article 3133990, How to
temporarily block the installation of the .NET Framework 4.6.1
<https://support.microsoft.com/en-us/kb/3133990>).
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