Maybe also consider tweaking  exim's various callout caching timers?

> - maintain a list of domains you never call out to
> - do as much envelope-checking as you can before triggering a callout
> (DNSBLs, verify=sender, SPF pass, HELO sanity)
> - expect to be listed by some agressive DNSBLs
> - don't go near SPAM-L


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