A recombinant feline .omega.-interferon preparation (Trade Name: INTERCAT) was administered to a 6-month-old crossbred female cat, which was observed to have neutropenia due to a feline leukemia virus infection.
On the first day of examination, the cat had a weight of 2.2 kg and a body temperature of 41.5.degree. C., and a complete loss of appetite, a loss of vigor, rhinorrhea, slaver, and dacryorrhea were observed.
Blood test results were as follows: PCV 32%, WBC 4,400,
neutrophil 2,885, lymphocyte 961, monocyte 732, eosinophil 0, and thrombocyte
100,000. In the virus test, an FeLV antigen was detected, an FIV antibody was
not detected, and a Parvovirus antigen was not detected.
The INTERCAT
was dissolved in a physiological saline solution, and was subcutaneously
injected at a dose of 3 MU/day for five days. The dose was 1.36 MU/kg per cat
weight. A transfusion (lactate Ringer's solution and glucose) was injected
by intravenous drip infusion at a dose of 500 ml/day, and an antibiotic
(cephalexin) was intravenously injected at a dose of 150 mg twice a day.
On the fifth day, the cat had a body temperature of 38.9.degree.
C., had an appetite, and rhinorrhea, slaver, and dacryorrhea were alleviated.
Blood test results were as follows:
PCV 26%, WBC 8,500, neutrophil 6,855, lymphocyte 1,020, monocyte 425, eosinophil 170, and thrombocyte 200,000.
On the 13th day, aggravation occurred again. The body
temperature was 40.2.degree. C., anorexia was observed, and rhinorrhea,
slaver, and dacryorrhea were aggravated. Blood test results were as follows:
PCV 28%, WBC 7,000, neutrophil 840, lymphocyte 4,340, monocyte 1,680, eosinophil
140, and thrombocyte 200,000.
The INTERCAT was again subcutaneously
injected at a dose of 3 MU/day for four days. The transfusion or antibiotic
was not administered.
On the 17th day, the body temperature was
38.50.degree. C., and appetite and vigor had recovered. Blood test results
were as follows: PCV 24%, WBC 19,100, neutrophil 10,186, lymphocyte 7,003,
monocyte 1,782, eosinophil 127, and thrombocyte 200,000.
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