Example 6
A recombinant feline .omega.-interferon preparation (Trade
Name: INTERCAT) was administered to a 2-year-old crossbred male cat, which was
observed to have neutropenia due to a feline leukemia virus infection.
On the first day of examination, the cat had a weight of 3.9
kg and a body temperature of 40.4.degree. C., and lymphatic swelling was
observed. The cat had an appetite and vigor. Blood test results were as follows:
PCV 22%, WBC 5,800, neutrophil 696, lymphocyte 4,698, monocyte 116, eosinophil
290, and thrombocyte 200,000. In the virus test, an FeLV antigen was detected
and an FIV antibody was not detected.
After 5 days, although appetite and vigor were observed, the
body temperature was 39.2.degree. C., and blood test results were as follows:
PCV 22%, WBC 5,800, neutrophil 131, lymphocyte 4,963, monocyte 219, eosinophil
483, and thrombocyte 200,000.
The INTERCAT was dissolved in a physiological saline
solution and was subcutaneously injected at a dose of 4 MU/day for six days. The
dose was 1.03 MU/kg per cat weight. A transfusion (lactate Ringer's
solution and glucose) was injected by intravenous drip infusion at a dose of 500
ml/day, and an antibiotic (cephalexin) was intravenously injected at a dose of
100 mg twice a day.
On the second day after the administration of the INTERCAT,
the body temperature was 39.5.degree. C., and blood test results were as
follows: PCV 24%, WBC 4,200, neutrophil 400, lymphocyte 3,400, monocyte 200,
eosinophil 200, and thrombocyte 200,000.
On the fourth day, the body temperature was 38.7.degree. C.,
and blood test results were as follows: PCV 23%, WBC 5,000, neutrophil 1,150,
lymphocyte 3,100, monocyte 450, eosinophil 200, and thrombocyte 200,000. On the
seventh day, the body temperature was 38.9.degree. C., and blood test results
were as follows: PCV 18%, WBC 6,100, neutrophil 1,769, lymphocyte 3,050,
monocyte 1,220, eosinophil 61, and thrombocyte 200,000.
In this example, significant recovery of neutrophils
was not observed, and abatement of fever and improved general condition were
observed.
Take care,
Glenda
Our FeLV/FIV kitties & other stuff:
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