Hi. I remembered today that you should look into Cushings Syndrome. I do not know if cats get it, but dogs, horses, and humans do. It comes from too much cortisone (which depo  is a form of). Sometimes people develop it from their bodies producing too much, and sometimes from having a reaction to getting it supplemented long-term with steroid shots and pills. Common symptoms include weakness in the hind end and weight loss.  In horses they tend to grown strange long hair, but I think in humans it can result in hair thinning and in cats it might also. I believe the only cure is stopping the cortisone (and no real cure if it comes on without steroids being supplemented). 
Michelle

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