What is the dose, and why is she getting it? And why in her ears? You can actually give Benadryl orally to cats, the dosage is 1MG per pound, so since a tablet is 25MG, you'd need to give a little less than 1/2 a tablet to a 10 pound cat, or if you buy the capsules, you can dissolve the opened capsule's powder into a bit of water, shake well, and only give 1/3 of the liquid, OR use children's benadryl liquid, but I'm not sure the strength of that, so you'd have to do the math. When you say she is overgrooming, do you mean she is cleaning one spot until she has no hair left? For Mythic's skin itchies, I just used a good quality aloe cat shampoo and bathed him once a week, and it seemed to help him a lot. The vet gave me a special shampoo, but I found some stuff at the hardware store that seems to help even more. The stuff the vet sold me is made by Virbac, and it's called Epi-Soothe Shampoo (label says available through vets only, and no number). The stuff that works better for Mythic, is made by TropiClean, and it's called Aloe Moist Natural Shampoo (1-800-542-7387). I wont ever buy any other kind of shampoo again, it's really awesome stuff, smells great too. Mythic also got shots at the vet for a while, I'd have to dig up his records to tell you what it was though. They only last for a couple of weeks, wasn't really worth the trip. Changing his food to one with no grains helped more than anything, his hair is still thin, but he does not scratch much at all now.
 
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DD is still overgrooming with the benadryl cream.  It doesn't seem to effect her.  Her dosage is 1mL twice daily (alternate ears) do you remember what you used?  I saved some other ideas I may try next, but the pharmacist said my prescription was a very 'low' dose.  I wonder if my vet prescribed a low dose because she didn't think it would work and I insisted on trying it?  My vet can be like that............
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