I have also used periactin with good results but have used it with not much effect to - it depends on the cat and can be very good in many cases. I am wondering about the amitryptilline though. I maybe thinking completely wrong here because I am going off how antidepressents work in humans - so correct me if this is completely off track. If the problem is more anxiety based minus the depression then antidepressents can actually make symptoms worse unless it is a depressive induced anxiety then it could help. That is what can happen in humans but not sure about cats. And likewise if depressive induced anxiety is treated with anxiolitics then it can make it worse but anxiolitics would help anxiety alone when depression is not present. However, I've known amitryptilline medication to help cats with skin conditions as it fools them into thinking they don't care about the itchyness etc... I've know cats to be put on fluoxetine too but I personally don't think I'd risk that one.
 
Michelle, Minstrel, Buddy & Angel Bramble

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