Hi, Belinda, I posted it on anemia list, I think - but here's the extract from marvistavet site --
> In one study 2 out of 3 dogs treated for more than 90 days with human > erythropoietin > and 5 out of 7 cats treated for more than 180 days with human > erythropoietin > developed refractory anemia due to anti-erythropoietin antibodies. > A more commonly reported statistic is a 30% incidence in development of > refractory anemia. > > After discontinuing erythropoietin, antibodies wane over 2-12 months and > the red cell count returns to its pre-treatment level. Blood transfusions > may be needed to keep the patient alive during this time. here's the link http://www.marvistavet.com/html/erythropoietin.html<http://www.marvistavet.com/html/erythropoietin.html> And Dr. kathy who participated in this study 1998 quoted as follows; "Having worked on the Amgen-sponsored clinical trial of Epogen in cats I can clearly say that no, not all cats get antibodies to human-recombinant erythropoietin. Based on the clinical trial, the % varied a little between Ohio State, UC-Davis, and U of MN patients, but it is about 1/3. Because the antibodies, if they form, are cross-reactive to the cat's own endogenous erythropoietin, they are very serious and the anemia that result will be severe (generally requiring multiple transfusions) until the antibodies wear off. We've had cats on Epogen for over 2 years without antibodies, so I think the majorty of cats' immune systems never recognize it as foreign." So, 30% came from 1/3, I believe. I had started on epogen on Ayumi thinking that 5 to 10% stas which is not that bad.. but if I had known that the stats could be as high as 30% - I would have thought more about using epogen, but instead I would have used aranesp instead. __._,_.___ ----- Original Message ----- From: Belinda<mailto:[EMAIL PROTECTED]> To: [email protected]<mailto:[email protected]> Sent: Friday, June 29, 2007 12:44 PM Subject: Re: To Belinda: Re: Anemia Issues > again 30% to 50% of cats will develop antibody, I believe this is a very high estimate, where did you get this number Hideyo?? -- Belinda happiness is being owned by cats ... Be-Mi-Kitties http://bemikitties.com<http://bemikitties.com/> Post Adoptable FeLV/FIV/FIP Cats/Kittens http://adopt.bemikitties.com<http://adopt.bemikitties.com/> FeLV Candlelight Service http://bemikitties.com/cls<http://bemikitties.com/cls> HostDesign4U.com [affordable hosting & web design] http://HostDesign4U.com<http://hostdesign4u.com/> ------------ BMK Designs [non-profit animals websites] http://bmk.bemikitties.com<http://bmk.bemikitties.com/>
