Dear Koichiro,
Nice that you have left your hibernation for a while!
I quite agree with your excellent comment. On the one side the
bookkeeping of molecules has plenty of tools to ascertain what is
happening with each other in an uncorrelated way (state variables,
force/mass/ energy, entropy, enthalpy, Helmholtz free energy, Gibbs free
energy, etc.). But trying to synchronize their happenstances becomes
daunting: tough external constraints have to be entered in order to keep
a decent bookkeeping and make useful workings. And this is where the
bookkeeping of life starts: building upon cycles as basic functional
constraints: the work cycle of the individual enzyme, the multiple
reaction cycles, the life cycle of the whole bacterium or the
unicellular. In aggregate, the life cycle is the great referent of
biological information, and the source of its "meaning". It is this
different inner reference what makes invalid the maximum entropy
principle for life--sometimes it is followed, sometimes it is just the
opposite. It depends on the intertwining of external "signals" and on
the advancement of the self-production process.
And with this I have already spent my "two cents" for the week...
best
--Pedro
PS. After the crash the list has more complex management (that I cannot
handle very well) and message processing. People willing to check
whether their messages have passed or not may directly check at:
http://listas.unizar.es/pipermail/fis/
Koichiro Matsuno wrote:
At 9:14 PM 09/05/2014, Pedro wrote:
Who knows, focusing on varieties of bookkeeping might be quite productive!
[KM] Pedro, your kick was loud enough to waken me up from my long
hibernation. Suppose there are many things popping up here and there
concurrently with no synchronization among them on the spot. Then, we would
be totally at a loss what to do when asked to tell what is going on there.
One plan as a last resort would be to make an appeal to a scheme of
synchronization even if conceivable out of the blue. One candidate would be
Bob U's energy, in reference to which we can safely say which are
synchronized and which are sequential. One more candidate of this sort might
be a reaction cycle of a natural origin, since any component reaction going
round the cycle is ipso facto made synchronous with the occurrence of the
cycle itself.
Koichiro
--
-------------------------------------------------
Pedro C. Marijuán
Grupo de Bioinformación / Bioinformation Group
Instituto Aragonés de Ciencias de la Salud
Centro de Investigación Biomédica de Aragón (CIBA)
Avda. San Juan Bosco, 13, planta X
50009 Zaragoza, Spain
Tfno. +34 976 71 3526 (& 6818)
pcmarijuan.i...@aragon.es
http://sites.google.com/site/pedrocmarijuan/
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