I am using Microsoft EMET, and recently upgraded to version 5.2 As a test I added all the apps that I often use to the EMET Apps list. So also PSPad (latest beta version 2653). With the default settings of EMET (Maximum security settings) PSPad is blocked with the following message: "EMET detected SimExecFlow mitigation and will close the application: PSPad.exe". When deactivating the SimExecFlow option for PSPad it starts normally.
Although this very likely is a false positive, it might be good to have a look at it. -- <http://forum.pspad.com/read.php?4,64593,64593> PSPad freeware editor http://www.pspad.com