PSPad from version 4.5.9 is code signed with COMODO issued certificate. Maybe there is some problem with EMET and certificate?
When I made quick research, I found that there can be a problem with TLS. Can you try to remove libssl32.dll and libeay32.dll from PSPad folder? This is a part of OpenSSL and it's used to FTP secure connection -- <http://forum.pspad.com/read.php?4,64593,64596> PSPad freeware editor http://www.pspad.com
