I tried; I changed toolbar icon set to "PSPad classic" It saved file. and turned back "PSPad".
Now icon behaves normal operation. It is very strange. _Answers to your questions_ *File is a local file. * not in read only mode * PSPad doesn't show message * ctrl+s saves file Sincerely -- <https://forum.pspad.com/read.php?4,73798,73803> PSPad freeware editor https://www.pspad.com