Susan Mosher wrote:

Greetings Freesurfers,

I am using optseq2 for the first time to generate a stimulus order for my
trials and figure out the ideal ITI between trials. I have a few questions
about how this works.

1. I tried specifying the PSD max as 18 seconds and minimum of 2 seconds. My ntp is 216 and my TR is set at 2 seconds. I have 9 events specified, each 14 seconds long with two repetitions of each. Here is the command I ran:

optseq2 --ntp 216 --tr 2 --psdwin 2 18 --ev ev1 14 2 --ev ev2 14 2 --ev ev3 14 2 --ev ev4 14 2 --ev ev5 14 2 --ev ev6 14 2 --ev ev7 14 2 --ev ev8 14 2 --ev ev9 14 2 --o test --nsearch 1000 --nkeep 100

In the par files that are generated, many of the NULL time durations are
much longer than the PSD max I specified (i.e., I specified 18 seconds and some are as long as 58 seconds). Is this simply because the duration of my
trials is so long that 18 seconds is not long enough of a max PSD? Does
optseq2 just ignore my max PSD request if it is unrealistic?

The PSD max is the time the HRF needs to return to baseline. If your event lasts 14 sec, then you'll probably need at least 14 sec more, so setting it to 28 or 30. The PSD max has little to do with the duration of the nulls. Use --tnullmin and --tnullmax to control the null duration. Also, you have a lot of fixation in there (90 time points out of 216), so it will have to do something with them.


2. Overall, I will have nine runs. While I realize that the mean ITI will
remain the same in each par file, I want to minimize the duration of any
single given ITI. As such, if I pseudorandomly select only 9 par files with the lowest maximum ITIs, is this acceptable? Is there some reason I would not want to do this?

I think it will be fine.


3. If I wanted to change my TR from 2 seconds to 1.8 seconds, would it be
acceptable to use the same trial order/ITI randomizations as I selected that were generated with a 2 second TR, or would I have to generate new ones? This is more a matter of whether I have to make new stimulus lists than running optseq2 again.

That's probably ok too.

doug


Many thanks,
~Sue Mosher


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Susan M. Mosher
Program in Neuroscience
Boston University
2 Cummington Street, Room 209F
Boston, MA 02215-2425
[EMAIL PROTECTED]
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Douglas N. Greve, Ph.D.
MGH-NMR Center
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