Hi,
We've noticed that FDR correction produces different p-values for the
left and right hemispheres. We found that this issue was observed
previously and an email was sent to the mailing list (see below),
however, no answer was received. We wondered if anybody has noticed this
problem before and if there are any suggestions on how best to deal with
it.
Thanks
Manja
Hi,
FDR correction for multiple comparisons gives you different p-values
for the left and right hemispheres. It seems really weird to report
in a paper:
a) that you've corrected for the right and left hemispheres
separately and
b) that the p-value that gave rise to a corrected probability of .05
was different for each.
How do people deal with this issue? Take the most stringent p-value
and use it for both hemispheres? Just report that FDR adjusted the p-
value to .05?
Also, correcting for right and left hemispheres separately assumes
that they are independent observations. Unless you're studying
callosotomy patients (and maybe even if you are) this doesn't seem
justified. Are we supposed to be adjusting p-values accordingly?
Thanks,
Dara
--
Manja Lehmann
Research Assistant
Dementia Research Centre
University College London
Institute of Neurology
Queen Square
London WC1N 3BG
[EMAIL PROTECTED]
Tel: 020 7837 3611 ext. 3962
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