Thank you very much Michael for an extensive answer. I am doing analysis in QDEC, thank you for pointing that, I will check the list.
On Wed, Nov 2, 2011 at 2:52 PM, Michael Harms <mha...@conte.wustl.edu> wrote: > > Oops -- I missed that aspect of your question. Yes, that would make > sense, and is precisely what we did in a 2010 paper in Brit J Psychiatry > (196:150-7). Although the measures in that paper were not FS-based, we > used appropriate "global" volume, area, and thickness measures to covary > for each respective type of measure (see paper for details). > > As an aside, are you analyzing the area of parcellated regions, or are > you doing a vertex-wise "area" analysis in QDEC. If the latter, you > should be aware that there are issues as to whether the vertex-wise area > values are a meaningful, interpretable measure since the area of any > given triangle of the mesh is more reflective of the mesh tesselation > than an intrinsic property of that subject's brain (see previous posts > regarding that as well). > > cheers, > -MH > > > On Wed, 2011-11-02 at 14:39 +0100, Tetiana Dadakova wrote: >> Thank you Michael, >> >> I was wondering about a nuisance specific to area analysis. I >> understand using ICV or brain volume in volumetric analysis, but for >> area analysis something like "overall pial area" seems more logical to >> me. That is why I am curious if there is any literature about area >> (surface) analysis in particular. Am I at the right track at all? >> >> Best wishes, >> Tanja. >> >> On Wed, Nov 2, 2011 at 2:15 PM, Michael Harms <mha...@conte.wustl.edu> wrote: >> > >> > Typically one uses either a measure of "brain volume" or an estimate of >> > intracranial volume -- the choice depends on whether or not you want to >> > control for whole brain atrophy when making your interpretations, in >> > which case you would use "brain volume" rather than ICV. There have >> > been numerous posts to the list on this issue, so try searching the >> > archives. >> > >> > As for articles, you could start with the ones below. >> > >> > cheers, >> > -MH >> > >> > >> > 1: Mathalon DH, Sullivan EV, Rawles JM, Pfefferbaum A. Correction for >> > head size >> > in brain-imaging measurements. Psychiatry Res. 1993 Jun;50(2):121-39. >> > Erratum in: >> > Psychiatry Res 1994 Sep;55(3):179. PubMed PMID: 8378488. >> > >> > >> > 2: Arndt S, Cohen G, Alliger RJ, Swayze VW 2nd, Andreasen NC. Problems >> > with ratio >> > and proportion measures of imaged cerebral structures. Psychiatry Res. 1991 >> > May;40(1):79-89. PubMed PMID: 1946842. >> > >> > >> > 3: O'Brien LM, Ziegler DA, Deutsch CK, Kennedy DN, Goldstein JM, Seidman >> > LJ, >> > Hodge S, Makris N, Caviness V, Frazier JA, Herbert MR. Adjustment for >> > whole brain >> > and cranial size in volumetric brain studies: a review of common adjustment >> > factors and statistical methods. Harv Rev Psychiatry. 2006 >> > May-Jun;14(3):141-51. >> > Review. PubMed PMID: 16787886. >> > >> > >> > 4: O'Brien LM, Ziegler DA, Deutsch CK, Frazier JA, Herbert MR, Locascio JJ. >> > Statistical adjustments for brain size in volumetric neuroimaging studies: >> > some >> > practical implications in methods. Psychiatry Res. 2011 Aug >> > 30;193(2):113-22. >> > PubMed PMID: 21684724. >> > >> > >> > 5: Sanfilipo MP, Benedict RH, Zivadinov R, Bakshi R. Correction for >> > intracranial >> > volume in analysis of whole brain atrophy in multiple sclerosis: the >> > proportion >> > vs. residual method. Neuroimage. 2004 Aug;22(4):1732-43. PubMed PMID: >> > 15275929. >> > >> > >> > On Wed, 2011-11-02 at 12:26 +0100, Tetiana Dadakova wrote: >> >> Dear FreeSurfer experts, >> >> >> >> I have a question regarding pial area analysis. >> >> >> >> What is commonly used as a nuisance variable to correct for brain size >> >> difference between groups (e.g men vs women)? Can you suggest any >> >> article where this is discussed or has been done? >> >> >> >> Thank you, >> >> Tanja. >> >> _______________________________________________ >> >> Freesurfer mailing list >> >> Freesurfer@nmr.mgh.harvard.edu >> >> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer >> >> >> >> >> >> The information in this e-mail is intended only for the person to whom it >> >> is >> >> addressed. If you believe this e-mail was sent to you in error and the >> >> e-mail >> >> contains patient information, please contact the Partners Compliance >> >> HelpLine at >> >> http://www.partners.org/complianceline . If the e-mail was sent to you in >> >> error >> >> but does not contain patient information, please contact the sender and >> >> properly >> >> dispose of the e-mail. >> > >> > >> >> _______________________________________________ >> Freesurfer mailing list >> Freesurfer@nmr.mgh.harvard.edu >> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer > > _______________________________________________ Freesurfer mailing list Freesurfer@nmr.mgh.harvard.edu https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
