Thanks very much, Douglas.
That is very helpful -- definitely newbie questions ...

Regards,
 
Don
 
Don Krieger, Ph.D.
Department of Neurological Surgery
University of Pittsburgh
(412)648-9654 Office
(412)521-4431 Cell/Text


> -----Original Message-----
> From: [email protected] [mailto:freesurfer-
> [email protected]] On Behalf Of Douglas N Greve
> Sent: Friday, August 15, 2014 12:22 PM
> To: [email protected]
> Subject: Re: [Freesurfer] language questions+
> 
> 
> On 08/12/2014 01:25 PM, Krieger, Donald N. wrote:
> >
> > _segmentation vs parcellation_:
> >
> > Segmentation appears to mean identifying and assigning voxels to a
> > label which maps to a gross structure like thalamus, left cortex, etc.
> > Parcellation appears to mean the same but for mappings at higher
> > resolution, e.g. L V1. Is this correct?
> >
> Actually, they basically mean the same thing. "segmentation" emerged from
> our volume tools and parcellation emerged from our surfaces tools.
> The segmentation format is a single index assigned to each voxel that then
> indexes a look up table where it gets color and name. The parcellation format
> stores an RGB at each vertex, then uses this RGB to index into a LUT to get
> the name.
> >
> > _surface vs volume_:
> >
> > My questions here arise from differences in the results of extracting
> > labels when using mri_cor2label vs mri_annotation2label.
> >
> > Spot checks of mri_cor2label results show sets of pixels on a 1 mm
> > grid which fill the volume associated with the label.
> >
> > I have been assuming that this is "volume" although volume also refers
> > to what is captured in the .mgz files.
> >
> Right, when a label is derived from a volume, the xyz must be on the grid of
> the volume. For surfaces, they must be on the surface mesh, but this is not a
> grid. You'll also notice that labels derived from volumes will have -1 as the
> first column (the vertex index, which makes no sense for volumes, of course,
> so -1)
> >
> > Spot checks of mri_annotation2label results show sets of pixels which
> > appear to delineate boundaries or "surfaces" of the gray matter
> > (--surface orig), white matter ( --surface white) or pia (--surface
> > pial).
> >
> > There appears to a similar switch in the help text for mri_cor2label,
> > i.e. -surf subject hemi <surf>, but it appears to specify the nature
> > of the input rather than that of the output as does the -surface
> > switch in mri_annotation2label. This leads to my next question
> > regarding the input "volume" but first, is what I've said correct so
> > far? An addition concern that I have is that "surface" may be used in
> > reference to a projection onto the sphere.
> >
> This gets back to your first question about segmentation vs parcellation. In
> FS, parcellations are always on the surface. However, segementations can be
> volume or surface. If you have a segmentation on the surface and want to
> create a label, then you use cor2label and spec the --surf. This will fill 
> the first
> column of the label with the vertex number instead of -1 and the xyz will
> derive from the surface you give it.
> >
> > _input volumes_:
> >
> > Here I have only tried the .mgz files contained in directory
> > ${FREESURFER_HOME}/subjects/NNN/mri .
> >
> > Which of these files are useful as input to mri_cor2label for
> > outputting .label files that are likely to accurately fill the
> > structures to which the label corresponds?
> >
> > What I mean here is which ones represent the end-points of a
> > processing stream and which ones are intermediates?
> >
> > I understand that the intermediates are likely useful given that they
> > are being saved in the standard processing streams.
> >
> aseg.mgz for non-cortical structures. For cortical structures, you can use
> ?h.aparc.annot (or possibly aparc+aseg.mgz)
> >
> > If I load them into freeview, specify the standard color map, and
> > place the cursor on the cerebellum, I can see which ones give the
> > right answer, e.g. aparc.a2009, wmparc, aparc+aseg, aseg.auto, and
> > which don't, e.g. filled, wm.seg, wm, rh.ribbin, brain,
> > brain.finalsurfs, T1, orig (of course). But "filled", for instance,
> > does appear to provide a good segementation of the left and right
> > supra-tentorial white matter although the colors (right=127; left=255)
> > do not map to those names in the standard color table.
> >
> filled, brain, brainmask, brain.mask.finalsurfs are intermediate volumes doug
> >
> > Regards,
> >
> > Don
> >
> > Don Krieger, Ph.D.
> >
> > Department of Neurological Surgery
> >
> > Universityof Pittsburgh
> >
> > (412)648-9654 Office
> >
> > (412)521-4431 Cell/Text
> >
> >
> >
> > _______________________________________________
> > Freesurfer mailing list
> > [email protected]
> > https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
> 
> --
> Douglas N. Greve, Ph.D.
> MGH-NMR Center
> [email protected]
> Phone Number: 617-724-2358
> Fax: 617-726-7422
> 
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