Hi Emma,

I might not be the only one who is unsure what you mean by a vertex-wise 
cortical surface area measure.  Do you mean something like what is illustrated 
in figures 2 and 3 here:

http://www.pnas.org/content/107/29/13135.figures-only

… which is similar, but not identical to the local gyrification index?

If so, would you use this measure on surfaces before or after registration to a 
target atlas?

Donna


On Oct 10, 2014, at 4:19 PM, Emma Thompson <[email protected]> wrote:

> Dear Freesurfers,
> I recently heard that there are several disadvantages to using a measure of 
> cortical surface area in Freesurfer, specifically due to conducting a 
> vertex-wise analysis. Can someone help me understand why a measure of surface 
> area using this approach might be flawed? Thanks!



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