Thanks! But it looks this script keeps looking for the lh.gwdist00N forever, 
here is the error message: 

mri_compute_layer_fractions: could not load lh surface 5 from 
/Users/emilyUS/Documents/Cortical_layer/Data/anatomical/Rest-Anatomical/output/surf/lh.gwdist005

I do not have lh.gwdist005. How can I set up the number in this code?

> On Sep 1, 2015, at 11:08, Bruce Fischl <[email protected]> wrote:
> 
> no, you just need to name them in the way that 
> mri_compute_layer_fractions is expecting (e.g. lh.gwdist000 for white, 
> etc...)
> On Tue, 1 Sep 2015, Yun Wang wrote:
> 
>> I do have 5 intermediate surfaces, should I combine them together?
>> 
>>> On Sep 1, 2015, at 10:43, Bruce Fischl <[email protected]> wrote:
>>> 
>>> you need to use mris_expand to generate the family of intermediate surfaces
>>> 
>>> 
>>> cheers
>>> Bruce
>>> On Tue, 1 Sep 2015, Yun Wang wrote:
>>> 
>>>> Hi all experts,
>>>> I have the error message when trying to use  mri_compute_layer_fractions.
>>>> mri_compute_layer_fractions $SUBJECTS_DIR/fMRI/register.lta
>>>> $SUBJECTS_DIR/white_lh.mgz  test
>>>> reading registration 
>>>> file/Users/emilyUS/Documents/Cortical_layer/Data/anatomical/Rest-Anatomical/fMR
>>>> I/register.lta
>>>> regio_read_register: loading lta
>>>> regio_read_register: loading lta
>>>> reading 
>>>> volume/Users/emilyUS/Documents/Cortical_layer/Data/anatomical/Rest-Anatomical/out
>>>> put/mri/aseg.mgz
>>>> reading laminar surfaces from gwdist.?
>>>> reading 
>>>> surface/Users/emilyUS/Documents/Cortical_layer/Data/anatomical/Rest-Anatomical/out
>>>> put/surf/lh.gwdist000
>>>> Anyone know the gwdist? how I can get it?
>>>> Thanks!
>>>> Yun Wang
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