And I would say if you want to do T1w/T2w myelin mapping the T2w scan will
give you more contrast for that, as the fluid inversion does seem to
reduce your contrast for myelin some (though it may increase your contrast
for CSF).  FLAIR can be useful for other things (like seeing some kinds of
brain lesions more easily) so your choice might depend on what else you
want to do with the images.

Peace,

Matt.

On 7/18/16, 6:59 PM, "Bruce Fischl"
<freesurfer-boun...@nmr.mgh.harvard.edu on behalf of
fis...@nmr.mgh.harvard.edu> wrote:

>Hi Michelle
>
>that's a tough question. We don't have a ton of experience with it one
>way or the other, but if I had to pick one I would pick FLAIR as long as
>you are getting a 3D FLAIR with around 1mm voxels
>
>cheers
>Bruce
>On Mon, 18 Jul 2016,
>Michelle T Kassel wrote:
>
>> 
>> Hello, 
>> 
>> 
>> I am beginning a new study and would like to determine the
>> optimal T2 acquisition parameters for improved pial surface
>> results from FreeSurfer. I am wondering if there is a difference in
>>using a
>> T2 or T2-FLAIR. I have found a discussion post from 2014 which provided
>> useful 
>>information(https://mail.nmr.mgh.harvard.edu/pipermail//freesurfer/2014-J
>>uly/039580.ht
>> ml), however, it seems from reading the post that newer developments
>>were
>> underway, and I was wondering if I could get an updated answer to the
>> question:
>> 
>> 
>> is there any difference from freesurfer's perspective of using T2-space
>>or
>> T2-space-flair?
>> 
>> 
>> Thank you for your help!
>> 
>> 
>> Michelle
>> 
>> 
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