yes, that is correct. However, understand that there might only be a 
difference of 1mm between those two locations, so it could easily be a 
partial volume effect


On 01/11/2017 08:50 AM, John Anderson wrote:
> Thank you Doug,
> Exactly! I meant GM near the CC.
> When I used "projfrac=0.5 " there was no differnce between the groups 
> at "cwp 0.05", and when I changed the "projfrac to 0" I got 
> significant differnce between the groups in specific areas at "cwp 
> 0.01". Kindly, how can this be explained? I highly appreciate if you 
> help me to understand this point:
> For "projfrac =0" I expect the surface based analysis to 
> be running close to white matter. Right? and when I used 
> "projfrac=0.5" the analysis is running in the middle area between pial 
> and white. When the analysis is not showing any differne between the 
> groups for "projfrac 0.5" and showing differnce for "projfrac 0" that 
> means the differnce between the groups is deeper and closer to white 
> matter. Is this correct?
> Thank you for any input and clarification!
> Bests,
> John
> *Sent:* Tuesday, January 10, 2017 at 10:51 AM
> *From:* "Douglas Greve" <gr...@nmr.mgh.harvard.edu>
> *To:* freesurfer@nmr.mgh.harvard.edu
> *Subject:* Re: [Freesurfer] surface based analysis (projfrac)
>
> When you say in the corpus callosum, do you mean in WM? The 
> surface-based analysis is only for cortical GM. If you mean in GM near 
> the CC, then the analysis is appropriate. The projfrac parameter sets 
> the sampling location between the white and pial surfaces where 0.5 
> means half way.
>
> On 1/10/17 8:07 AM, John Anderson wrote:
>
>     Dear FS experts,
>     I am working on surface based analysis using freesurfer. I want to
>     inquire about the flag "projfrac" in the command "mris_preproc"
>     I ran voxel wise analysis including the same subjects. I found
>     differnce between the groups in areas close to the corpus
>     callosum. I want to get the same results using surface based
>     analysis. If I use the projfrac=0.5 is this able to show the same
>     results that I got in voxel wise analysis at the level of the
>     corpus callosum. Do I need to use differnt number for projfrac ?
>     Thank you for any advice.
>
>     Best,
>     John
>
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-- 
Douglas N. Greve, Ph.D.
MGH-NMR Center
gr...@nmr.mgh.harvard.edu
Phone Number: 617-724-2358
Fax: 617-726-7422

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