Hi Doug,

Thanks for your response! I had a couple follow-up questions:


1) If I used mri_fit_parms to calculate the T1 maps, then created a surface 
mid-cortex (with mris_expand) with that T1 map as a reference, and uploaded 
that file into MATLAB through MRIread, would the resulting values represent 
absolute "pure" T1 values?


2) Even though we are scanning on a Siemens scanner we have been acquiring a 
tfl_mgh_multiecho_4E_P2_1MM_ISO sequence. Do you think I could do T1 mapping 
based on that sequence (with the same method as the one described in the 
previous question)?


Thanks again, and I apologize for the potential triviality of the questions!


Best,

Panos


Panagiotis Fotiadis
Senior Imaging Research Technologist
J. P. Kistler Stroke Research Center, Department of Neurology
Massachusetts General Hospital, Boston, MA
T: (617) 643-3869
________________________________
From: freesurfer-boun...@nmr.mgh.harvard.edu 
<freesurfer-boun...@nmr.mgh.harvard.edu> on behalf of Douglas Greve 
<dgr...@mgh.harvard.edu>
Sent: Friday, August 10, 2018 1:59:47 PM
To: freesurfer@nmr.mgh.harvard.edu
Subject: Re: [Freesurfer] T1 mapping

mri_fit_parms should do it. BTW, if you are using a siemens scanner, you should 
just collect an MP2RAGE. That automatically outputs a quantitative T1 map using 
the two inversion technique. The results are much more accurate than using 
multiple flip angles

On 8/8/18 5:00 PM, Fotiadis, Panagiotis wrote:

Hello,


I am interested in doing some T1-mapping analyses on some ex vivo brains. We 
have collected flash sequences under multiple flip angles (5, 10, 15, 20, 25 
and 30). How would you suggest that I proceed? Should I use the mri_ms_fitparms 
to come up with the T1 maps for each subject and then maybe calculate the 
signal intensity 1mm into the cortex, or is there another way that you would 
recommend?


Thanks in advance for any advice!


Best,

Panos


Panagiotis Fotiadis
Senior Imaging Research Technologist
J. P. Kistler Stroke Research Center, Department of Neurology
Massachusetts General Hospital, Boston, MA
T: (617) 643-3869



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