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Site effects, even from different scanners with comparable sequences, are a big 
issue is neuroimaging and discussed in many papers. I think you should be very 
careful with interpretation of results, especially since in your case, the 
scanners were different between the groups (!) and additionally operating at 
different T settings.

Tim

> On August 6, 2020 at 6:16 AM Haewon Roh <[email protected]> wrote:
> 
> 
>         External Email - Use Caution        
> 
> Hi.
> 
> Recently, I analyzed patients who have taken 1.5T MRI ; (Because they had
> to go in MRI room with some metal materials) and normal controls who took
> 3.0T MRI. And, after recon and preprocessing of each group of patients and
> controls in freesurfer v6, I've found that many cortices of patients (1.5T
> MRI) were significantly reduced, compared with normal age-sex matched
> controls (3.0T MRI). When I searched in order to know if there is
> difference between 1.5T vs 3.0T MRI and magnetic field can make a huge
> difference in calculating volumes or thickness of cortices in Freesurfer, I
> can find only one article by Heinen and his colleague, reporting there is
> no big difference and different(1.5 vs 3.0T) magnetic field strength cannot
> make a significant difference. (Plos ONE, 2016)
> 
> Furthermore, given that data which is taken in 1.5T MRI is more likely to
> have more increased volumes or thickness of cerebral cortices than those of
> 3.0T MRI, I think that reduced cortical volumes which are calculated using
> 1.5T MRI have more significance than controls of 3.0T MRI...
> 
> Is it true that different magnetic strengths of MRI cannot change the
> result significantly in Freesurfer?
> 
> Thank you always!
> 
> 
> -- 
> Hae Won ROH, M.D.
> 
> H.P: +82-10-4341-8142
> E-mail: [email protected]
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--
Dr. Tim Schäfer
Postdoc Computational Neuroimaging
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy
University Hospital Frankfurt, Goethe University Frankfurt am Main, Germany

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