What surface feature are you exvaluating? If thickness, then don't do
normalization by eTIV or surface area or anything else
On 5/23/2022 11:20 AM, Rafael Navarro wrote:
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Hello FreeSurfer Developers,
I am building a brain age model from the stats extracted with
FreeSurfer. I tested my model normalizing volumes by eTIV, which I
think is the recommended, and surfaces by WM total surface. For
surfaces, I haven't found any recommendations. I am getting better
results by using the features without normalization.
From what I have read, volume normalization clearly should be
performed, but I am in doubt about the surface normalization.
Although, the surface is different depending on head size and along
with lifespan, I am not sure if all cortex surfaces evolve the same
way, and therefore that normalization might be adding noise to my
results. Then, is it correct to normalize my surface features by the
total WM surface? Does anybody know any reference that talks about the
topic or have done similar work?
Thank you for your support
-----------------------------------
|| Rafael Navarro González
|| Ph.D. Student
|| ETSI Telecomunicación
|| Universidad de Valladolid
|| Campus Miguel Delibes
|| 47011 Valladolid, Spain
|| e-mail: rafael.nava...@uva.es
|| Phone: +34 672 394 294
||_________________________________
-----------------------------------
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