Can you be even more specific? Operationally, what does it entail? Are you just trying to correlate, say, cognitive deficits to, say, thickenss?

On 2/25/2024 9:12 PM, Martin Juneja wrote:

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Hi Doug,

Sorry for not elaborating in my previous email.

Voxel lesion symptom mapping (VLSM) is a method to calculate symptom localization by estimating statistical relationships between damage to specific brain regions (it could be stroke lesion, tumor lesion or TBI lesion etc.) and resulting deficits (e.g., *MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724038/ <https://secure-web.cisco.com/1UiWVbssc136ehHR7fbKC3mJg7kJQVmdWhaRoU7E29vpu5yNgNVpd0lZiq4aR019jbUXsgd9ifhWAi0IlkNaX6x9xio5om5mkSpOTNvua1cW-cEEjvzxDi3L2sB29VZVsnhEZ8Tb3UH9P0xee7U6UR5dzGEOh8QJNPNhtL65F1jvipA-Phq6I6tlLdM_es5V3bNy-Uc2GG6yXw2BY9-tSYOxCFzZ8xvUgiqlPE8H6y5TPAXxx9g0S5ELQ2MYBhZc4scdk6uSlw8_4_qsmFzE3pHqfDGZ0Q_Jv3szY1k1AqHkxkI9t7LPh8R6dSgTpNeL4WUyRopXxirT8r-0IxK7nYA/https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4724038%2F> and *MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be* https://academic.oup.com/brain/article/137/9/2532/2848278 <https://secure-web.cisco.com/1Sv3DQt7ECt7yYskA3qSYiurVnqwYgQMrW8bVWoluBQmsM_yLtTYU5rsNedrt7kfxvXWRFNBdsUI4A1g3RXw72SMBIG6ZQrrv9cyiZQGDsnk8bidCzCK_lFen7x0alY7ZhJs5O1HBwG06GFvTNxoPfkbR1hD87w8QzlmPBxoAV_migSoy78DKyb73PilyF7D9vRCcWNAx4UOdo0SSrO_Shf1_py0ygzhtUB2FOJo-0Z-5e1wnn3cKO0-MJMcDUhRdVzUXTYWyey2rVOBEqbKBye_yDzoaxLIKzESNFAVFJGY8t8AlAjZS0kE9aqzZKXXtHqmihL1X2aNJDuA_eQsRZA/https%3A%2F%2Facademic.oup.com%2Fbrain%2Farticle%2F137%2F9%2F2532%2F2848278>). This method can guide the development of targeted interventions and rehabilitation strategies aimed at improving symptoms by targeting specific brain regions (or networks, if we use network lesion symptom mapping: *MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724189/ <https://secure-web.cisco.com/10LgUitf4Y4lehNjHOInoyAOPPrjXpKyw8QudhBNFrI-HEs531siCcOCZApchqgDvWDYKy7cM6QODz-i1dQPhiBuCX-00bXDcm2EF8XZrhB_Rknetjx1FVS8u1BBOZ16mMYnGswaNPzNgbt15-7OR0ZajBrz3jJMaAXx2tGeFbJuIT_cwpTPX2u7uVcKu40byzK3CksUD9sBXUODMzo1dWFYJ7dqv9jzjPyhXiM51d49k7iGamx_SlWvcrdjka0R328JXdXbqwiXqt2FEwAVsz1ioBdFbSPNdth73sqgmm1hDt5vQsBMMp8Txr8bGJeZxE6q-ZHf8yqwxiFsXOOVtBw/https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC9724189%2F>).

On Fri, Feb 23, 2024 at 10:27 AM Douglas N. Greve <dgr...@mgh.harvard.edu> wrote:

    Sorry, don't know what VLSM is. Can you elaborate?

    On 2/6/2024 3:19 PM, Martin Juneja wrote:

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    Dear FreeSurfer community and experts,

    I would greatly appreciate any help/response with the following.

    Thanks.

    ---------- Forwarded message ---------
    From: *Martin Juneja* <mj70...@gmail.com>
    Date: Wed, Jan 31, 2024 at 7:51 PM
    Subject: Vertex / voxel lesion symptom mapping
    To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>


    Greetings FreeSurfer community,

    I was just wondering if it's possible to perform vertex/voxel
    lesion symptom mapping (VLSM) using FreeSurfer? In other words, I
    would like to assess the impact of lesion topography (of course,
    heterogenous locations across patients) on
    neurocognitive function in brain tumor patients.

    I would greatly appreciate any help/response.

    Thanks!

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