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Hi Sara,

You need to denoise the background.
Here are some links that might be of help. Always check the quality of the 
output :-)

https://secure-web.cisco.com/11TUQn3ZMjB9gy2mI09erMcLASzJWGpSLFMUxf9tT-XFEDmLfZKdF-O_LIYc_Nlr6rt_zg2mZoh6G-ql4JyDGF9_GKBWGdH3JuQ9aAlzf3dfm7rvxhqKlc2uv5mqmYsc80zjn13a6yKfhlR0WWmUwhZwpGhy5H1vp1y6xKh7DtnYHIGn0HPT11eZFwcabo11doDCbL7I-040PqCDs-uSRWD8uen0ehnSSf9vTMhRoSEsFCjRWI6Bwpj9JUFQtkdyHhOkGLZa0e_LtMmTgeHXhYyBAgp8BZBkCm0NnpqC0vbDOqKNHqNt7xRa7KBZZC34m231hyY_tw-e5GA9WTOZy7Q/https%3A%2F%2Fgithub.com%2Fsrikash%2FMP2RAGE-utils%2Fblob%2Fmain%2Fcore%2Fmp2rage_func%2FRobustCombination.m
https://secure-web.cisco.com/1_MN1cYA-kKEagHaPPlgqZwL_7l1UIz17_aQNq8gtEpI_s21m5q0Dk-NNA1GpJ0qz9MZylJZTxfNcdHX6oB-Rd6NTRfG9Y7jvYF3YzCZLUOYKgXKYMLpRYsrx2wWUK_cjaAiqIhc881eAujRSsciwbSOrxXuehaPX0gLR7hc9oyJZVj9RI85MzrVJz-duGY0dL9vGepgc2rq7jO6cdYUeO6clS9WxY9Dvs0N_9RQGWPPYnX0etEEV-ON5j0NWWAxlVwBD_JhtBGwUGOhfVZsS_yoKAxKl_pyMOywN1q18lMvKjUNSGqxqBPNYszM0E0D1rn-06aymELBVZfXQvQ1Y4g/https%3A%2F%2Fgithub.com%2FJosePMarques%2FMP2RAGE-related-scripts
https://secure-web.cisco.com/1zawiMfJEYesgKKwuXbwTzApr_RjlOcUDaWo3xqmb9Q0qqTasKaAlNOngj40ZYQOPj1lps9A4U4IntfCY1H_dCm9_uvGl7FwRP_hXSywB_PIEVdsnxY3PmSiPodCYxMIvbfOP3kwl3CRf3U98UsZdhtf2AZ9FzSs4inSytMusfZZa9UuDR9pjtnCY0TABMZq5bUXv_e_QLuh0zURQ_TkWX3ZnXeSlDGEM5z7q1BbbDnIN75GsqHOvkNWKFpywV9SnRE7a-X3lxrO1dSfD34CTW9y1Ei4FjRpxqi_u89IM_xSQ7lSpO0o6pTMIUWDxpXb1q7mujDwj04A_W37-73k0sA/https%3A%2F%2Fgithub.com%2Fsrikash%2Fpresurfer%3Ftab%3Dreadme-ov-file
https://secure-web.cisco.com/16BjhjRriW3CRUsbQApyaWMd2fGPbTX5BssSvzhZZyLbnz8_i4PtLRN5QiZUcz7HQ_uei4EmIroeeBnKGIQxmbI6rI-oWfDmO-sexqor-PvDOj0L9wt1gJcipUPnylZtByZKt_dmEbcfENd5Km6WN9dia3cv5AVbhCRmMagEiz_CMGS2hSdZ3VTzyvZ-E-qId7CEFs4yGgxvSVv8Xv7PNjMj2-DlRTDQpM8DpyDYwxmSoIbjxuXX2rkXi3yCDAi0p-vPHVkef_ki37h51GAFsaB6grbd8raSV3wwMkBePUtw_HHkOyDRFN5qnCDI_GSVXiz7faKdJuKEuyU-jLwbADA/https%3A%2F%2Fgithub.com%2Fsrikash%2F3dMPRAGEise

https://secure-web.cisco.com/18BI4v-eXbN8hzYHtzlbMkSCRqHbcR3o6WbRlxoakoEiyq6Y3Fxp9i-3PMN9Ha0O1QFXfqfL4t0D8KxpRCrFEUvpqUWseikOiP-oL_n-uIMVYPoIb9jt6o-tEUQdYtpoNEitW82YuWrsofv06RVCxqIEXYJZL2HZb7AJdhD5JDDeTBfgoiuDpSG6Fkq6DlldSEtub8IhshaapbeMoNd0ZpX4nj_6xo26xhG2SjkGMU-TOKtzrBUZ3-ks_WWCg0_H3ifEPYfxDL2NehLE_iDsUVGWNmBzdTtinfJHzvHOLvt5mmBUTiKQWx0aAzqCh6-5US--T3tJUqER31JXaLZYjtw/https%3A%2F%2Fsurfer.nmr.mgh.harvard.edu%2Fdocs%2Fsynthstrip%2F
   (incorporated in freesurfer)

Cheers
William 



> On 28 Sep 2024, at 18.27, De Giorgi, Sara <sdegio...@mgh.harvard.edu> wrote:
> 
> Dear all,
> 
> Skull stripping on Freesurfer failed due to MP2RAGE sequence. That’s the only 
> sequence we have. This is how it looks:
> <image.png>
> 
> This is how the skull stripping appears:
> 
> <image.png>
> 
> Please find the log file as an attachment.
> I also tried to manually adjust brainmask.mgz , but also brain.mgz is 
> incorrect.
> 
> How can I solve this issue?
> 
> Thanks,
> Sara
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