PS: the code is freely available (https://github.com/acasamitjana/uslr) it’s 
just that it’s not integrated into FreeSurfer. Actually, if you try it, Adrià 
and I would love your feedback 😊

--
Juan Eugenio Iglesias
http://www.jeiglesias.com

From: Iglesias Gonzalez, Juan E. <jiglesiasgonza...@mgh.harvard.edu>
Date: Tuesday, July 1, 2025 at 8:18 PM
To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
Subject: Re: Measuring longitudinal changes in brain volume using SynthSeg
Hi Marco,
We’ve built a wrapper method around it. We just got it published but haven’t 
found the time to make it easily usable (also, the first author is on leave…). 
But we’ll get there 😊
https://www.sciencedirect.com/science/article/pii/S1361841525002099
Cheers,
/Eugenio

--
Juan Eugenio Iglesias
http://www.jeiglesias.com

From: Marco Ganzetti <marco.ganze...@biogen.com>
Date: Tuesday, July 1, 2025 at 11:31 AM
To: freesurfer@nmr.mgh.harvard.edu <freesurfer@nmr.mgh.harvard.edu>
Subject: [Freesurfer] Measuring longitudinal changes in brain volume using 
SynthSeg

        External Email - Use Caution
Does SynthSeg offer any functionality for estimating longitudinal changes in 
segmented brain volumes beyond simply subtracting values from two time points?
Marco
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