http://nautil.us/blog/the-problem-with-the-mutation_centric-view-of-cancer

> How should we study the origins of cancer? 
> 
> My lab has been researching the origins of cancers for the last 15 to 17 
> years. We’re trying to understand cancer from an evolutionary viewpoint, 
> understanding how it evolves. A lot of people think about cancer from an 
> evolutionary viewpoint. But what sets us apart is that we’ve really come to 
> understand cancer by the context these cells find themselves in. 
> 
> What’s an example of such a context? 
> 
> While other people will think about aging as the time for mutations to cause 
> advantageous events [for cancer] in cells, we see aging as a very different 
> process. It’s not about the time you get mutations—you get many mutations 
> when you’re young. It’s the tissue environment for the cells that changes 
> dramatically as we age. Those new tissue environments basically stimulate the 
> evolution. So the evolution isn’t a process that’s limited by the mutation so 
> much as a process that is limited by micro-environment changes.


-- 
␦glen?

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