Hi Karen, Whenever one goes out on a limb, as I did yesterday in my piece ("Move over, America"), one immediately retreats mentally and wonders whether it's so. At least I do. For the rest of the day, as I went about my normal jobs, I wondered whether I had gone too far in saying that if America fails to develop the nascent technology of organ replacement then China might take over as the next economic power in the next decade or two.
(I must also declare a personal interest in this matter because three of my grandchildren are triplet girls who were produced by in vitro fertilisation -- which I'll briefly return to later.) My case essentially depends on deciding just what the consumer demand might be if perfectly-matched organ replacements could be bought in order to prolong life. By the end of the day, after I had wobbled somewhat, I'd returned to my early morning view -- that this is almost certainly going to be the most sought-after product of all time (after food and water). I'd intended to let the matter drop so I could continue to ponder it at leisure over the coming weeks/months but, lo and behold, the matter came up on BBC Radio news this morning. This concerns another byproduct of stem cell research. It involves an English couple who have a son, Zain, who suffers from thalassaemia, an incurable genetically-linked blood condition from which he will inevitably die. The couple proposed to produce embryos in vitro from which one will be selected that closely matches their existing son's DNA but without the thalassaemia propensity. The selected embryo will then be implanted in the mother. Then, at the birth of the child, the stem cells from the unbilical cord will be harvested and then used to treat Zain. This has been popularly termed as a 'designer baby'. (Actually I'm not sure whether the new child's umbilical stem cells are needed or whether his/her bone marrow will be used for Zain. But no matter, it's the same issue.) This procedure was allowed to go ahead by a committee called the Human Fertilisation and Embryology Authority (HFEA) which is given some degree of authority by an Act of Parliament in 1990. The HFEA is an unelected body and contains a mixture of specialists and non-specialists -- including liberally-inclined people of the sort I mentioned yesterday (who generally seem to be shaping up against radical biogenetic research). An intense controversy has already arisen because, the Zain researchers say, the HFEA took far too long in coming to a decision (which, of course, they welcomed). Prof Austin Smith, a leading stem cell researcher at the University of Edinburgh, said that the HFEA was not only slow but "lacking in specialist knowledge". On the other hand, Life, other pro-life groups and fundamentalists have forcefully objected to the decision. And, on top of that, some politicians have now pitched in saying that the HFEA exceeded the authority given to it by Parliament. Going back a few years, the HFEA were involved in a previous controversy of great public interest. A Mrs Blood, whose husband was in a deep coma (after a road accident and from which he didn't recover) asked some specialists to extract his sperm and put it in deep freeze. This they did. But Mrs Blood was obliged then by the 1990 Act to ask the HFEA if her husband's sperm could then be used to fertilise her own eggs. The HFEA decided against this. There was an uproar from the general public, of course. Mrs Blood then went to the High Court and won her case that she should at least be allowed to keep her dead husband's sperm as her rightful inheritance. Mrs. Blood then took her dead husband's sperm to specialists in another country (Denmark I think) and one of her eggs was fertilised in vitro, re-implanted and she had a son. (Coincidentally, two days ago, she had another son by the same father and the same procedure.) Now then, let's put the ethical controversy to one side (by being gracious in saying that both sides have a strong case in theory), and dwell on the customer aspect. Years previously to Mrs Blood's and the Zain case, there arose the controversy of in vitro fertilisation in principle. There were very strong pressures by pro-life groups for this to be forbidden but desperate mothers-to-be, like my daughter, prevailed, and this is why the 1990 Act was passed and the HFEA was formed. What I'm saying here is that, at the end of the day, the customer will prevail if there is a sufficient desperate need. Therefore, sooner or later, radical research into cloning and stem cells will have to be allowed by law because there'll be too much intense pressure. I've no doubt that the law will be relaxed in both America and England in due course so that (to choose just one case) organ replacement research can continue. The matter in hand, however, is *when*. Because of the intense pressure from American religious fundamentalists, who have a sizeable chunk of votes, then freedom for human cell cloning is surely many years away. (Some years ago America was falling very badly behind some Asian countries in computer chip design and manufacture and, by a supreme effort of politicians and commerce, managed to set up an R&D fund from which America managed to regain supremecy after a few years. But in that case, there was no resistance from any part of the electorate. It was just a matter of overcoming commercial inertia.) I suggest, therefore, in the case of human cell cloning, that a required change of legislation is going to be intensely controversial and protracted in America, England and several European countries, even while Lu Guangxiu and other researchers in China forge ahead. My apologies that this has been yet another long piece on something that may not interest you directly. But this started from my main thesis that empires come and go on the basis of the leading technologies of the day, and America's turn for going is now probably due (even though America is not a territorial empire in the old-fashioned sense). China has huge problems of corruption, massive unemployment, totally bankrupt state banks and may, in fact, collapse in the next decade or so as a major economic power. But somehow I think not. China has had a longer civilisation than any other country on earth, despite three intermissions -- the fast-disappearing communist one being the last. My money is therefore on China as being the next predominant economic power, not because it has the capacity to export large quantities of very cheap products into the West (the consideration that economists usually dwell on) but because it is now resuming its traditional role of being a supremely inventive culture, and is now already leading in the most complex technology of any in mankind's history -- and for which there'll be an unstoppable customer demand. The looming battle over human cloning research will, in the West, test our 'democratic' governmental systems to the limit I believe. Indeed, I think our present sorts of governances will actually fail this particular test for a long time to come. In comparison, the present corruption scandals in America are pretty minor, and if Bush fails to bring about radical reform, this will be but a preliminary in leading to a much larger failure of our present sort of governmental system in dealing appropriately with anything that is of great importance. (And, in modern times, our problems in most areas are more crucial than ever before.) We need a new type of 'policy forum' type of governance, not the present sort of jamboree. The morning's newspapers have arrive. My dog is pestering me. It's dog-walk time! Keith ---------------------------------------------------------------------------- ------------ Keith Hudson, General Editor, Handlo Music, http://www.handlo.com 6 Upper Camden Place, Bath BA1 5HX, England Tel: +44 1225 312622; Fax: +44 1225 447727; mailto:[EMAIL PROTECTED] ________________________________________________________________________