Harry,

I agree a great deal with what you wrote -- and with your basic assumptions
that "we have 'unlimited desires' that we seek with the 'least exertion'
pressed by a 'basic curiosity'. 

That's fine when we are talking of economics broadly, but it doesn't get us
far when we consider the political systems that intervene in the process.
It doesn't explain freeloaders, for example, or for the fact that human
history is littered with the phenomenon of tyrants -- which, whether we
like it or not, have considerable repercussions in the production and
distribution of resources. For some sort of understanding of these
phenomena, we have to turn towards our genetic inheritance, particularly
when we see the costly humanitarian failure of large-scale "nurturism" in,
say, the recent history of USSR or China up until about ten years ago.

Why Steven Pinker's book, "The Blank Slate", is important is that, for the
better part of a century at least, we humans have considered ourselves as
somehow outside the normal evolutionary process which has refined us and
shaped us -- for good and for ill -- over the course of tens of thousands
of generations. Whatever the nurturists may say, we are still mainly a
product of evolution even though we have been interfering with this since
the dawn of the welfare state without much thought as to where this is
taking us.

I am not suggesting that we should change the political philosophy in
developed countries overnight. Even it that were possible, it would cause
chaos. What I'm suggesting, however, that we should give much more room to
the views of the new human sciences -- of biogenetics and evolutionary
psychology. Otherwise, we are in very real danger that, as our state
education and welfare systems continue to crumble, a proportion of the
population will be voting with their money and carry out eugenics on their
own and their childrens' account and tend towards a very real prospect of
speciation, as discussed in books such as "Remaking Eden" by Lee Silver,
and a growing number of others.

The following article from The Guardian of 5 February 2001 makes the case
fairly, I believe.
  
<<<<
THE ETHICS OF GENETICS

Johnjoe McFadden
 
According to yesterday's Mail on Sunday, the Queen has "sparked a furious
row" by investing in a bio-pharmaceutical firm, ReNeuron. One of the firm's
alleged crimes is that it has supported legislation allowing the cloning of
human embryos. 

Whatever the merits of this particular case, the fact remains that, if
mankind is to escape an enfeebled future, we must embrace this scary
technology. Detractors are quick to remind us of the dangers of designer
babies once we remove our parents from their role as exclusive providers of
our genes. But, like it or not, if humanity is not to become an endangered
species, we must face up to the challenges of genetic engineering. 

The reason is the same one that brought us here -- natural selection. Over
millions of years, the simple mechanism that Darwin first described -- let
the strong survive and the weak perish -- has turned us into the successful
animals we are today. Every gene in our bodies has been passed, baton-like,
from parent to offspring over millions of years. But our genes are not
unchanged by their passage through the generations. Replication of our
chromosomes introduces errors called mutations. 

All children acquire a few mutations on top of those inherited from their
parents. Occasionally these will make our children run a little faster or
think more quickly than ourselves, but mostly, they will do harm. Our genes
have been finely tuned to do a particular job inside our cells. Mutations
are, by and large, random. Just as random tinkering with your car engine is
likely to leave you stranded the next morning, random tinkering with your
genes is like to leave your offspring similarly stranded. 

In our brutal past, defective genes would have been weeded out by natural
selection, their owners suffering disease, predators or infertility. Modern
medicine has changed all that. In the west at least, many of us survive and
lead active lives with gene mutations that would have been fatal to our
ancestors. I'm not talking about single-gene defects like cystic fibrosis
or muscular dystrophy that remain devastating, but the far more frequent
mutations that predispose us to ailments like diabetes, heart disease or
cancer. 

A few hundred years ago, a child with diabetes would have been lucky to
survive to adult life. Thanks to insulin injections, diabetics now have
nearly as much chance as the rest of us to leave their genes to the next
generation. The same is true for scores of other diseases. Infant mortality
in Palaeolithic times was probably higher than 50%. Bad genes, or bad
combinations of genes, didn't make it through to the next generation. Now
we see most of our offspring provide us with grandchildren, whatever their
genetic inheritance. Where does this leave Darwinism? 

Natural selection needs the grim reaper. Without his cruel separation of
the fit from the weak, we will grow weak. We are healthier and will live
longer than our parents, but our genes are not improving. Modern medicine,
and improved living conditions, rescue us from our imperfect genetic
inheritance. 

In Britain we spend less on healthcare than almost any other wealthy
country, but 6.7% of everything we earn goes to keeping us alive. Each
government promises to spend more. Health advisers may pin their hopes on
lifestyle changes to reduce the burden of disease, but most of the risk for
cancer and heart disease is in our genes. As our genes become more faulty,
our bodies will require more and more medical intervention. Use it or lose
it is the advice of physiotherapists to those with mobility problems. It
applies equally well to genes. 

The provision of healthcare has brought about the greatest shift in
selective pressure on the human species since we came down from the trees.
The grip of the grim reaper has been loosened and our genes are free to
roam the murky paths towards ill-health. 

The consequences will take many generations to be realised, but they are
inevitable. There is no way to stop mutations accumulating in our genes. As
long as we have a health service to carry the burden, genes that introduce
disease will multiply. We will become enfeebled parasites of our health
systems. It's as inevitable as taxes. 

Where will it all end? Is it our fate to become a frail and sickly species
with chromosomes shot through with mutations? Perhaps the end will come
when the NHS waiting list embraces the entire population and the burden of
healthcare finally exceeds our capacity to provide it. 

Many of the founding fathers of genetics were proponents of eugenics as a
means of improving the human stock. If the horrors of that particular
vision are not to be repeated we must find an ethical way of ridding our
bodies of faulty genes. 

ANDi, the first GM monkey, is a step towards that solution. The same
technology that inserted a jellyfish gene into his chromosome will be used
to correct defective human genes. We must see ANDi, not as a danger, but as
our only hope for the future. 

Johnjoe McFadden is reader in molecular microbiology at the University of
Surrey and author of "Quantum Evolution", published by HarperCollins.
>>>>

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Keith Hudson,6 Upper Camden Place, Bath BA1 5HX, England
Tel:01225 312622/444881; Fax:01225 447727; E-mail: [EMAIL PROTECTED]
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