We had intermittent issues like this for an embarrassingly long time
at MSI, but since we applied this patch
https://bitbucket.org/galaxy/galaxy-central/pull-request/36/fix-for-dynamic_optionspy
Galaxy has been running smoothly for weeks. Seems unlikely this is the
problem in your case (unless you have pulled in tools with make use of
dynamic options), but it something to consider.

-John

On Wed, Feb 29, 2012 at 2:08 PM, Joshua Gross <gros...@students.wwu.edu> wrote:
> Hi all--
>
> Our group is running a local instance of Galaxy on a Linux box.  We have
> been noticing a memory issue, where if we leave the server running for a few
> days, soon all available memory (~8gb) will be used up to the point where
> the tools fail because they are unable to allocate new memory.
>
> While we haven't done any rigorous testing, this issue seems to be
> independent of the specific tools we run, and actually seems to still appear
> if we do not run any tools at all.  The process "python" is what is taking
> up all the memory, and the issue is not instantaneous but happens over
> time.  Restarting the server frees the memory immediately.
>
> Is this a known issue?  If so, is there a known fix for it?  Any insight on
> this would be much appreciated, as it is complicating our efforts to
> automate long work-flows.
>
> Thank you so much for your time
>
> Josh Gross, Western Washington University.
>
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