Dear Dr. Kuryavyi,
The telemere regions are comprised primarily of
heterochromatin repeats and have not been sequenced. The
regions are annotated in our gap tables using the data
from the reference sequence provided by the sequencing
centers. We use the gap annotation and the sequence of Ns
to indicate the best estimate of their size. The NNNN
sequence is essentially a placeholder.
best wishes,
--b0b kuhn
ucsc genome bioinformatics group
On Fri, 21 Nov 2008 14:02:43 -0500
"Vitaly V. Kuryavyi" <[EMAIL PROTECTED]> wrote:
> Dear colleague,
>
> When I look at the ends of the chromosomes in the genome
>browser, I
> do see the telomeric sequences in some cases and I see
>letters NNNNN
> in some other.
> 1)How reliable is the information about the sequences at
>the ends of
> chromosomes?
> 2)In the files with the chromosome sequences at NCBI
>(Watson and
> Venter), telomeric sequences are missing. What is the
>source of
> telomeric sequences, in the cases when they are
>explicitly present,
> in your website?
>
> Thank you.
> --
> Vitaly V. Kuryavyi, PhD
> Program in Structural Biology
> Memorial Sloan-Kettering Cancer Center
> Box 557
> 1275 York Ave
> New York NY 10065
>
> e-mail: [EMAIL PROTECTED]
> phones: 1(646)-888-3033 (Zuckerman Research Building)
> 1(212)-639-2194 (Rockefeller Research
>Laboratories)
> 1(917)-292-7179 (Cell)
> fax: 1(212)-717-3657 (RRL)
> 1(646)-888-3035 (ZRB)
>
> _______________________________________________
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> http://www.soe.ucsc.edu/mailman/listinfo/genome
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