Hello David,

We are currently looking into your question and will get back to you as 
soon as possible. Thank you for your patience.

Best regards,

Pauline Fujita
UCSC Genome Bioinformatics Group
http://genome.ucsc.edu


On 11/12/10 07:45, David Garfield wrote:
> Hi folks,
> 
> I've two general questions. The first is simply a software question. I see 
> from the FAQ that y'all generally use both Repeat Masker and TRF to deal with 
> repeats, and that repeats are soft-masked. I know how to soft-mask using 
> Repeat Masker, but how does one do this on TRF?
> 
> Second, I've seen at least one paper 
> (http://www.biomedcentral.com/1471-2105/11/80) that strongly suggests that 
> repeats should be hard masked. Has this (relatively recent) paper changed 
> your thoughts on hard-masking?
> 
> Many thanks,
> 
> David Garfield
> Duke University
> _______________________________________________
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