Hi 
I am using standalone BLAT for querying est sequences againt human,
mouse and rat genome. 

I am using the following command:

'./blatDir/blat -noHead  databaseFiles queryFile tmpPslFile'

here the database and query files are in FASTA format. 

I blat for rat est squences (total est sequence for rat is around a
million) but it is taking time in days. I am intimidated by the toughts
when I will start doing it for human and mouse. 

Can I do something to tune the parameters so that  it becomes even more
fast(I am becoming more greedy). 

In one of the archives it is recommended to use ooC file but since BLAT
internally create it, do I really need to do that?

Thanks and regards 
Fahim
Grad Student 
University of Louisville
KY-USA

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