Hello David, We do not have a single tool to append data to bigWig files as you describe, however, there is an easy way to accomplish this with existing utilities. Simply extract the data from your big* file (i.e. with bigWigToBedGraph) merge the resulting extracted file with your new data (i.e. you could merge the resultant bedgraph file with a new bedgraph file) and then convert back to bigWig using bedGraphToBigWig.
Note that this utility (bedGraphToBigWig) will require that at most one value is listed for each base pair. The reason for this is because bigWig keeps track of summary information at different resolutions so it doesn't have to look at each base pair when looking at large chrom ranges. To calculate these zoom levels, the bigWig builder needs to look at all the data. Best regards, Pauline Fujita UCSC Genome Bioinformatics Group http://genome.ucsc.edu On 02/09/11 06:05, Davide Cittaro wrote: > Hi all, > I'm extensively using bigWig format for ChIP-seq data. I usually have a > single bedgraph I can convert to a bigWig using witToBigWig executable. This > said, I may have in the future the need to merge multiple dataset and/or > writing bigWig at different times (i.e. append data to an old bigWig). Is > this possible with current binaries (and current bigWig implementation, of > course)? > > Thanks > > d > /* > Davide Cittaro, PhD > > Cogentech - Consortium for Genomic Technologies > via adamello, 16 > 20139 Milano > Italy > > tel.: +39(02)574303007 > e-mail: [email protected] > */ > > > > > _______________________________________________ > Genome maillist - [email protected] > https://lists.soe.ucsc.edu/mailman/listinfo/genome _______________________________________________ Genome maillist - [email protected] https://lists.soe.ucsc.edu/mailman/listinfo/genome
