Hello,
I have aproblem regarding the different ucsc builds- hg18 and hg 19.
 For hg18,In a certain location in the genome, the reference is G. For hg19-
same exact location, reference is C. the amino acid is also changed between
versions- from R to P. How can I know which one is more accurate? how can I
tell whether I have a SNP in a patient if I compare it to the ref in hg19
and I get a SNP, but in hg18 the patient has the normal genotype?

I would highly appriciate your help.

Thanks
Danit

-- 
 Danit Oz-Levi, PhD student
Department of Molecular Genetics
Weizmann Institute of Science
Rehovot 76100, Israel
Tel: 972-8-9342455
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