Hi Danit, The builds are not expected to have the same sequence at the exact same coordinates. The hg19 build is newer than the hg18 build. There are links to much more information on both builds on the gateway page of the Genome Browser: http://genome.ucsc.edu/cgi-bin/hgGateway (select either assembly and scroll down)
For your SNP, you will need to find out which build coordinates were used to find/report the SNP. I hope this is helpful. If you have further questions, please send them to [email protected]. -- Brooke Rhead UCSC Genome Bioinformatics Group On 06/29/11 06:18, Danit Oz-Levi wrote: > Hello, > I have aproblem regarding the different ucsc builds- hg18 and hg 19. > For hg18,In a certain location in the genome, the reference is G. For hg19- > same exact location, reference is C. the amino acid is also changed between > versions- from R to P. How can I know which one is more accurate? how can I > tell whether I have a SNP in a patient if I compare it to the ref in hg19 > and I get a SNP, but in hg18 the patient has the normal genotype? > > I would highly appriciate your help. > > Thanks > Danit > _______________________________________________ Genome maillist - [email protected] https://lists.soe.ucsc.edu/mailman/listinfo/genome
