In 1996 and thereafter we have described the Recombination Enhancer that is a cis-acting element which directs the use of HML in homothallic switching of MATa but is repressed in MATalpha (thus leading to the preferential use of HMR). It is approximately 250 bp in size and lies about 17 kb to the right of HML. If you need more help in defining it, see Wu C, Weiss K, Yang C, Harris MA, Tye BK, Newlon CS, Simpson RT, Haber JE. Genes Dev. 1998 Jun 1;12(11):1726-37.) RE binds Fkh1, Mcm1 and Swi4/6 in MATa cells but is repressed in MATalpha by binding Matalpha2-Mcm1, a repressor of a-specific genes.
I hope you will consider putting this landmark on your map James E. Haber Abraham and Etta Goodman Professor of Biology MS029 Rosenstiel Center Brandeis University Waltham MA 02454-9110 781-736-2462 (phone) _______________________________________________ Genome maillist - [email protected] https://lists.soe.ucsc.edu/mailman/listinfo/genome
