Phillip

No, because prescriptions are outpatient and so are orders placed in clinic for 
direct administration of a drug or immunologic.  Both may be part of an 
outpatient encounter-  to respond to Russ's proposal.

I do believe it is possible however to separate the two types of orders in 
Epic, and I presume, in Cerner.

Jim

________________________________
From: [email protected] [[email protected]] on 
behalf of Phillip Reeder [[email protected]]
Sent: Thursday, September 29, 2016 10:13 AM
To: Shelley Rusincovitch; Russ Waitman
Cc: [email protected]
Subject: Re: [Data.pcornet] Confirming medications sources for Antibiotic 
obesity study question

Would the inpatient vs outpatient flag from med orders be good enough to 
determine if an order was for dispensing or administration?  The documentation 
states that the outpatient flag would be used for things like take-home meds in 
during an inpatient encounter so I think it might. Thoughts?

Phillip

From: Shelley Rusincovitch 
<[email protected]<mailto:[email protected]>>
Date: Wednesday, September 28, 2016 at 6:50 AM
To: Phillip Reeder 
<[email protected]<mailto:[email protected]>>, 
Russ Waitman <[email protected]<mailto:[email protected]>>
Cc: "[email protected]<mailto:[email protected]>" 
<[email protected]<mailto:[email protected]>>
Subject: RE: [Data.pcornet] Confirming medications sources for Antibiotic 
obesity study question

Hi Phillip,

This was an area that the original CDM working group really wrestled with, 
especially given that there wasn’t a lot of precedence in modeling practices. 
I’m quite interested in what your experiences have been, and it’s helpful to 
hear that this isn’t clear.

RX_BASIS was intended to connect the provider’s prescribing order with how the 
order was fulfilled. (The working group thought of this as the arrows 
connecting the domain boxes in the below diagram.) It was an area of 
consideration because the PRESCRIBING table can contain orders for many 
different activities. For example:

·        Order for an antibiotic to be delivered by a nurse in an outpatient 
clinic: RX_BASIS=Administration

·        Order for a painkiller to be delivered by a nurse in a hospital room: 
RX_BASIS=Administration

·        Order for a drug that will be dispensed at Walmart: RX_BASIS=Dispensing

The RX_BASIS would be set depending on the context of your data – I know that’s 
a little tricky, but do the examples help? Inpatient orders would generally be 
expected to be administration basis. We expected that EHR systems including 
Epic’s Willow would support this distinction (although I don’t want to make too 
many assumptions about your specific instantiation of Epic!), but it may not be 
feasible in all legacy systems or data sources.

Does this help? And just to mention that a feedback cycle for the new v3.1 
draft specification will be opening on Monday, October 3 – I hope that you and 
your team might consider contributing, perhaps including your thoughts on this 
issue?

Not everyone has been comfortable working directly in GitHub, but I’ve added 
this to our tracker and you’re welcome to add anything to the log: 
https://github.com/CDMFORUM/CDM-GUIDANCE/issues/22

Best wishes,
Shelley


From: Phillip Reeder [mailto:[email protected]]
Sent: Tuesday, September 27, 2016 7:49 PM
To: Russ Waitman <[email protected]<mailto:[email protected]>>
Cc: Shelley Rusincovitch 
<[email protected]<mailto:[email protected]>>; 
[email protected]<mailto:[email protected]>
Subject: Re: [Data.pcornet] Confirming medications sources for Antibiotic 
obesity study question

Can you explain what the rx_basis means?  Administration vs dispensing?  And 
what should it be set to for the medication orders?

Thanks,
Phillip

Sent from my iPhone

On Sep 27, 2016, at 6:36 PM, Russ Waitman 
<[email protected]<mailto:[email protected]>> wrote:
Thanks again Shelley,
Phillip, JimC and DanC: to follow up on today’s gpc-dev call, I’d like sites to 
load physician orders broadly encompassing all encounter types and then 
investigators can filter to what the desire by linking on encounter type.

That way the CDM would have utility for inpatient and emergency medicine (near 
and dear to Jim McClay).

Russ

From: Shelley Rusincovitch [mailto:[email protected]]
Sent: Tuesday, September 27, 2016 1:33 PM
To: Block, Jason Perry,M.D.; Russ Waitman
Cc: Charles Bailey; Casie Horgan; 
[email protected]<mailto:[email protected]>; Jessica 
Sturtevant; [email protected]<mailto:[email protected]>; 
[email protected]<mailto:[email protected]>;
 Christopher Forrest ([email protected]<mailto:[email protected]>)
Subject: RE: [Data.pcornet] Confirming medications sources for Antibiotic 
obesity study question

Hi everyone,

If it’s helpful from a general perspective, the CDM structures the PRESCRIBING 
table for any medication orders (regardless of whether it’s inpatient, 
outpatient, ED, etc). But this may be quite different than availability of 
these data.

Best wishes,
Shelley

<image004.png>


___________________________________________
Shelley A. Rusincovitch
Project Leader in Applied Informatics & Architecture
Duke Clinical and Translational Science Institute (CTSI)
[email protected]<mailto:[email protected]> / 
919-668-5954


From: 
[email protected]<mailto:[email protected]>
 [mailto:[email protected]] On Behalf Of Block, Jason 
Perry,M.D.
Sent: Tuesday, September 27, 2016 1:13 PM
To: Russ Waitman <[email protected]<mailto:[email protected]>>
Cc: Charles Bailey <[email protected]<mailto:[email protected]>>; 
Casie Horgan 
<[email protected]<mailto:[email protected]>>; 
[email protected]<mailto:[email protected]>; Jessica 
Sturtevant 
<[email protected]<mailto:[email protected]>>;
 [email protected]<mailto:[email protected]>; 
[email protected]<mailto:[email protected]>;
 Christopher Forrest ([email protected]<mailto:[email protected]>) 
<[email protected]<mailto:[email protected]>>
Subject: Re: [Data.pcornet] Confirming medications sources for Antibiotic 
obesity study question

Hi Russ.  Thanks for emailing - no bother at all.
I'm cc'ing a few others who have expertise in this issue (Charles Bailey at 
CHOP and Casie Horgan and Jessica Sturtevant on the DRNOC QF team).

We are not including inpatient medications in our study.  We made this decision 
for logistical reasons (we didn't think it would be available, or if available, 
it would be available in a highly variable way) and scientific (we are most 
focused on potentially modifiable antibiotic use, and inpatient use doesn't fit 
that categorization).  The scientific point is a debatable one, and we have had 
some subtle disagreement on the team about this.  But, ultimately, since it 
wasn't going to be available, we chose to pursue use of antibiotics prescribed 
in the outpatient setting.

Casie and Jessica might be able to respond to how we excluded meds in ED and 
Inpatient settings, if they did that explicitly.  Charlie has lots of 
experience with meds as well, so he might want to respond to this.

I could see how studies would like to include ED and inpatient med prescribing 
(or dispensing), and I would support inclusion of that in the CDM.  We just 
won't use for our study, as it's currently structured.
jb


________________________________
From: Russ Waitman [[email protected]<mailto:[email protected]>]
Sent: Tuesday, September 27, 2016 12:50 PM
To: Block, Jason Perry,M.D.
Cc: [email protected]<mailto:[email protected]>; 
[email protected]<mailto:[email protected]>; Christopher 
Forrest ([email protected]<mailto:[email protected]>)
Subject: Confirming medications sources for Antibiotic obesity study question
Dear Jason,
I hate to bug you but we wanted to get your quick check on something as the GPC 
sites are doing their CDM work in support of your study.

Apologies for not being as close to your study but wanted to confirm something 
about how the CDM is being loaded and potential implications for your study as 
it’s the first big thing using medications from the CDM.

The CDM 
http://pcornet.org/wp-content/uploads/2014/07/2015-07-29-PCORnet-Common-Data-Model-v3dot0-RELEASE.pdf<https://urldefense.proofpoint.com/v2/url?u=http-3A__pcornet.org_wp-2Dcontent_uploads_2014_07_2015-2D07-2D29-2DPCORnet-2DCommon-2DData-2DModel-2Dv3dot0-2DRELEASE.pdf&d=CwMF-g&c=imBPVzF25OnBgGmVOlcsiEgHoG1i6YHLR0Sj_gZ4adc&r=Vu1yqij3sPINGhACFSh38ArhXkVAmgx-t4FJu5KXbYY&m=7IGVk2QoYKMlC9tHPJrSA9IKFgzn3D2U48glbgYDBl8&s=yGtovUGBuLMyDvbiumYOYlrfIsuGXaxHNIIEr6pMYNo&e=>
on page 13 specifies that the prescribing tables and the dispensing tables 
should not contain

-          inpatient medication administrations

-          active medication lists resulting from medication reconciliation

Prescribing should obviously have outpatient prescriptions but it’s unclear to 
some regarding physician inpatient orders.  The table specification in written 
largely in language of outpatient prescriptions but the page 13 figure 
indicates that prescribing encompasses physician orders that spawn both 
dispenses and administrations.

I would just be concerned that if sites are conservative in only loading 
ambulatory meds, we’re going to have limited CDM data to support studies that 
want to include inpatient and emergency room medication exposures.

As you look at your early sites, what are you seeing?

Does that match what exposures you wish you had?

Bottom line: are you only looking at outpatient prescribing or dispensing 
exposure to antibioticsor does your study need inpatient and emergency room 
medication exposure?

My personal bias is to exclude the admins and the med rec at this point but 
include both inpatient and outpatient medication orders written by the 
physician.

Russ Waitman, PhD
Director of Medical Informatics
Associate Vice Chancellor for Enterprise Analytics
Professor, Department of Internal Medicine
University of Kansas Medical Center, Kansas City, Kansas
913-945-7087 (office)
[email protected]<mailto:[email protected]>
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