Ricardo Wurmus <ricardo.wur...@mdc-berlin.de> writes: > * gnu/packages/bioinformatics.scm (eigensoft): New variable. […] > + (description "This package provides tools for population genetics and > +stratification correction. The EIGENSTRAT method uses principal components > +analysis to explicitly model ancestry differences between cases and controls > +along continuous axes of variation; the resulting correction is specific to a > +candidate marker’s variation in frequency across ancestral populations, > +minimizing spurious associations while maximizing power to detect true > +associations. The EIGENSOFT package has a built-in plotting script and > +supports multiple file formats and quantitative phenotypes.")
Here’s an alternative description, which is a little more general and doesn’t emphasise EIGENSTRAT so much: The EIGENSOFT package provides tools for population genetics and stratification correction. EIGENSOFT implements methods commonly used in population genetics analyses such as PCA, computation of Tracy-Widom statistics, and finding relateds in structured populations. It comes with a built-in plotting script and supports multiple file formats and quantitative phenotypes. WDYT? ~~ Ricardo
