Christmas bark as good as its bite

Surajit Dasgupta in New Delhi / The Statesman
Dec. 24, 2004 � A fake Christmas tree may be more popular, but here's 
a new reason to appreciate the real thing: researchers have 
identified a group of anti-inflammatory compounds in the bark of the 
Scotch Pine � widely used as Christmas trees - that they say could be 
developed into food supplements or drugs for treating arthritis and 
pain. The compounds, which show promise in preliminary cell studies, 
are likely to be found in other pine species as well, the scientists 
say. 
This is believed to be the first time that 28 compounds have been 
identified in Pinus Sylvestris (Scotch pine), used commonly to make 
Christmas trees, the researchers say. The compounds identified were 
phenolics, a class of highly-active plant chemicals that have been 
increasingly tied to beneficial health effects. The study is 
scheduled to appear in the 29 December print-issue of the Journal of 
Agricultural and Food Chemistry. 
"The preliminary study showed that highly purified preparations of 
pine bark extract have potent anti-inflammatory effects. In future, 
this may mean that people with arthritis may ease their pain by 
eating food supplements made from Christmas trees," says study leader 
Kalevi Pihlaja, Ph.D., a chemistry professor at the University of 
Turku in Finland. Pine bark extract also has the potential to relieve 
high blood pressure, asthma, heart disease and skin cancer. The study 
may help provide an explanation for some of its supposed health 
benefits, Prof. Pihlaja says. 
The researchers have tested the various extracts against mouse 
inflammatory cells (macrophages) for their ability to produce nitric 
oxide and prostaglandin E2 (PGE2), chemicals which are known to help 
trigger inflammation when they are produced in excess amounts, as 
during disease or injury. The results were compared to the chemical 
responses of inflammatory cells that were not exposed to pine bark 
extracts. 
The researchers found that the highly-purified extract tested had the 
most potent anti-inflammatory activity. The extract (at 50 �g/mL 
concentration level) inhibited nitric oxide production, an excess of 
which has been linked to arthritis and circulatory problems, by up to 
63 per cent, they say. 









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