Hi team HCP,

I have two semi-related questions about generating resting-state gradients:

1) What is the theoretical motivation behind using cifti-correlation-gradient 
rather than cifti-gradient to generate a resting-state gradient .dscalar.nii 
from a .dconn.nii file, per this thread ( 
http://www.mail-archive.com/hcp-users%40humanconnectome.org/msg01431.html )? 
Based on the documentation, cifti-gradient takes the first spatial derivative 
of the input .dconn.nii (i.e. the correlation matrix of every voxel/vertex) and 
(optionally) averages them. Cifti-correlation-gradient, by contrast, first 
correlates the .dconn.nii correlation matrix, and then takes the spatial 
derivative of the resulting maps and averages them. What is the purpose of this 
second-order correlation?

2) Is it possible to generate volume-based dense connectomes and downstream 
resting-state gradients using the HCP tools? My goal is to examine 
resting-state gradients just beyond the edges of the subcortical volume as 
defined in grayordinate space.

Thank you for any feedback!
-Ely

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