Is your DWI data by any chance saved with an orientation other than LAS or RAS?

--
Michael Harms, Ph.D.
-----------------------------------------------------------
Conte Center for the Neuroscience of Mental Disorders
Washington University School of Medicine
Department of Psychiatry, Box 8134
660 South Euclid Ave. Tel: 314-747-6173
St. Louis, MO  63110 Email: [email protected]

From: 
<[email protected]<mailto:[email protected]>>
 on behalf of Maarten Vaessen <[email protected]<mailto:[email protected]>>
Date: Wednesday, October 19, 2016 at 6:50 AM
To: "[email protected]<mailto:[email protected]>" 
<[email protected]<mailto:[email protected]>>
Subject: [HCP-Users] alignment issues with diffusion data

Hello experts,

I have been trying to use the HCP Diffusion preprocessing pipeline for my own 
diffusion data. However, I run into a lot of issues at the final stage of the 
pipeline where the dwi data is registered to the T1w_acpc space (the freesurfer 
part of the pipeline runs fine on the structural images, the eddy correction 
also seems to run fine).
So far I have not had a single subject where this alignment went smoothly and 
was accurate.
It seems to be a problem with flirt. In the DiffusiontoStructural.sh subscript 
there are several calls to flirt (or epi_ref_dof) with the T1 as reference and 
for some reason flirt gives very wrong results like AP inverted or cerebellum 
to frontal lobe matching etc...
I have managed to solve some cases with a call to only flirt and not 
epi_reg_dof and adding -useqform to the flirt options, but some I only managed 
by doing a rough manual alignment first. When the initial reg to T1 in ok-ish 
the bbregister and later parts all work very well.
I don't think my dwi data is very special (1.5 mm^3 90 dir 2 shell), so I have 
no idea what might be the issue here or how to solve it (in a consistent way).

-Maarten

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