Hi,
I don’t think the following is necessarily your problem, but know that the 
simple tensor model is not appropriate at high b-values.  You should either
1)  use the “—kurt” or “—kurtdir" flags which will add a “mean kurtosis” or 
“parallel/perpendicular kurtosis” parameters that can account for 
non-exponential decay
or
2) limit the fitting to just the b=1000 shell (+ b=0’s).

cheers,
-MH

--
Michael Harms, Ph.D.
-----------------------------------------------------------
Conte Center for the Neuroscience of Mental Disorders
Washington University School of Medicine
Department of Psychiatry, Box 8134
660 South Euclid Ave.                        Tel: 314-747-6173
St. Louis, MO  63110                                          Email: 
[email protected]

From: <[email protected]> on behalf of "Glasser, Matthew" 
<[email protected]>
Date: Tuesday, October 31, 2017 at 3:57 PM
To: "Archer,Derek B" <[email protected]>
Cc: "[email protected]" <[email protected]>
Subject: Re: [HCP-Users] Inaccurate b0 Image from DTIFIT

That cannot be the command line as not all the parameters are present.  I agree 
that picture looks incorrect.  Does this happen consistently across subjects?  
What subject is this?

Peace,

Matt.

From: "Archer,Derek B" <[email protected]<mailto:[email protected]>>
Date: Tuesday, October 31, 2017 at 3:06 PM
To: Matt Glasser <[email protected]<mailto:[email protected]>>
Subject: RE: [HCP-Users] Inaccurate b0 Image from DTIFIT

Hi Matt –

I am only using one line of code, which is:

dtifit –mask=nodif_brain_mask.nii.gz –bvecs=bvecs –bvals=bvals 
–gradnonlin=grad_dev.nii.gz –out=prefix.

This is the exact line of code I run with data from our group, but instead of 
giving bright ventricles it’s dark.  I’ve attached an image of the Human 
Connectome data.

Derek B. Archer
Postdoctoral Research Fellow
Laboratory for Rehabilitation Neuroscience
(812) 259-0687

From: Glasser, Matthew [mailto:[email protected]]
Sent: Tuesday, October 31, 2017 3:08 PM
To: Archer,Derek B <[email protected]<mailto:[email protected]>>; 
[email protected]<mailto:[email protected]>
Subject: Re: [HCP-Users] Inaccurate b0 Image from DTIFIT

Please post the two command lines and some example images.

Peace,

Matt.

From: 
<[email protected]<mailto:[email protected]>>
 on behalf of "Archer,Derek B" <[email protected]<mailto:[email protected]>>
Date: Tuesday, October 31, 2017 at 11:56 AM
To: "[email protected]<mailto:[email protected]>" 
<[email protected]<mailto:[email protected]>>
Subject: [HCP-Users] Inaccurate b0 Image from DTIFIT

Hello all –

I am working on running DTIFIT on human connectome project diffusion data, but 
when I run the code using the gradnonlin option, the b0 image doesn’t look 
correct.

On a typical b0 image, the ventricles should be bright.  The output on all of 
my subjects gives me dark ventricles.  Is this inaccurate? Does DTIFIT work 
corrected with high b-values?

Thanks!
Derek B. Archer
Postdoctoral Research Fellow
Laboratory for Rehabilitation Neuroscience
(812) 259-0687


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